New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin.
نویسندگان
چکیده
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 microM (1), 1.7 microM (2) and 1.7 microM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 microM).
منابع مشابه
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Aromatic plants have been commercially used as spices, natural flavor, raw material for essential-oil industry and other medicinal purpose. The use of essential oils continues to rise, both as a separate commodity and indirectly through a large range of beautycare and aromatherapy products. Patchouli (Pogostemon cablin (Blanco) Benth; is a species from the genus Pogostemon and a bushy herb of t...
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Article history: Received 25 March 2014 Received in revised form 20 April 2014 Accepted 15 May 2014 Available online 10 June 2014
متن کاملDevelopment and Structure of Internal Glands and External Glandular Trichomes in Pogostemon cablin
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 52 12 شماره
صفحات -
تاریخ انتشار 2004